Peptide Therapy


Sermorelin is a synthetic peptide derived from an endogenous hormone called growth hormone-releasing hormone (GHRH). Similar to GHRH, sermorelin exerts its effects in the pituitary gland by binding to somatotroph cells leading to secretion of growth hormone.

Understanding Sermorelin

Sermorelin is a 29-amino acid peptide derivative of the endogenous peptide hormone GHRH, that retains the full functional activity of GHRH, due to the fact that the sermorelin peptide includes the GHRH receptor binding domain.

Sermorelin has a rapid half life of 11-12 minutes when administered via injection and exerts its effects by binding to the GHRH receptor at the pituitary gland. This leads to stimulation of growth hormone secretion by the pituitary gland, independent of changes to other hormones such as luteinizing hormone, follicle-stimulating hormone, prolactin, cortisol, glucose, glucagon, or thyroid stimulating hormone.

Benefits of Sermorelin

Similar to hGH administration, the most notable effects of sermorelin are aroundincreased lipolysis due to direct action of GH on adipose tissue and increased lean body mass due to upregulation of IGF-1 secretion [2, 10]. 

Due to these unique properties, sermorelin is useful to researchers interested in an alternative to exogenous rhGH administration that can produce the following effects, all otherwise associated with rhGH [7]:

  • Diagnosis of growth hormone deficiency
    • Treatment of low IGF-1 levels
    • Improvements in body composition and fat loss
    • Improved muscle strength and exercise performance
    • Increased skin thickness
    • Improved memory and well-being
    • Increased resting energy expenditure